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Research Scientist, Clinical and Nonclinical Assay Development

If interested and qualified, please include Requisition # 2016-129 in the subject line when emailing resume to: careers@crisprtx.com.

For more information on CRISPR Therapeutics, please click here.

Position Summary

We are seeking an experienced and self-motivated Research Scientist to join an exciting, fast growing and well financed company to develop novel gene editing therapies for serious diseases. This position will report to the Director of Preclinical and Clinical Assays. The successful candidate will be someone who can independently and efficiently perform method optimization, troubleshooting, and preliminary qualification of robust assays, and subsequent technological assay transfer to CROs. This position requires GLP-like method qualification, and designing and performing experiments in cellular and molecular biology including cell culture and genetic manipulation. The position requires enthusiasm, passion, attention to detail, and a desire to create important new medicines for patients.

Responsibilities

  • Efficiently perform method development, optimization and pre-qualification of molecular and cell biology techniques employing phase appropriate strategies, and knowledge of the fundamentals of rational experimental and assay design
  • Support multiple preclinical and clinical projects by qualifying and transferring assays and by providing technical expertise and troubleshooting, as needed
  • Plan, transfer and execute of critical assays, samples and reagents to CROs
  • Analysis and presentation of experimental data
  • Effectively communicate results and project progress, and discuss technical challenges to all appropriate team members
  • Manage critical time-lines and resource allocation

Minimum Qualifications

  • Advanced degree in Molecular/Cell Biology or other relevant field
  • MS with 15 years’ or PhD with 3 years’ experience in assay development and validation supporting preclinical activities
  • Extensive experience in developing and qualifying molecular biology techniques including, but not limited to, quantitative PCR (qPCR), DNA and RNA manipulations, and Sanger and Next Generation Sequencing (NGS) techniques
  • Considerable expertise in developing robust, reproducible methods utilizing mammalian cell culture, transfection and cell-based assays
  • Excellent oral and written communication skills
  • Ability to work independently as well as collaborate with peers and effectively work in a results oriented research team environment
  • Ability to travel, if required (less than 25%)

Preferred Qualifications

  • MS with 15+ years’ or PhD with 3+ years’ experience in assay development and validation supporting preclinical activities
  • Prior experience in method optimization and validation of cell and molecular biology techniques in the context of preclinical and clinical level studies
  • Experienced in droplet digital PCR (ddPCR) and Hybrid Capture and Whole Genome Next Generation Sequencing (NGS) techniques
  • Proficient in flow cytometry (FACS) assay development and qualification, including preparation of samples, analysis and cell sorting
  • Prior experience working in a Biotechnology company
  • Previous experience with coordinating and managing external projects at CROs
  • Basic knowledge of gene editing and CRISPR based technology
  • Experience working in a highly regulated GLP quality level environment, and
  • Excellent documentation skills

Competencies

  • Scientific Rigor/Attention to detail – Maintains high scientific rigor and attention to detail in designing and testing hypotheses and analyzing data. Challenges assumptions, demonstrates highly organized thinking and documentation.
  • Creativity/Innovation - Creates a boundary-less environment that fosters curiosity and taking risks, is able to test, confirm or refute scientific hypothesis effectively and efficiently. Open to new approaches, alternative points of view and methodologies. Able to be opportunistic.
  • Communication and Teamwork – Effectively expresses ideas in written, visual, and oral context. Able to work co-operatively with others; the genuine desire to be a part of a team and contribute to organizational and team goals.
  • Passion - Creates an exciting environment where there is a true passion for the vision of CRISPR Therapeutics to bring novel medicines to patients suffering from serious diseases.
  • Results Orientation / Productive Work Habits – Drives issues to closure and gets the job done. Skilled at analyzing scope of work, as well as planning and executing a successful outcome. Understands and assigns / utilizes resources effectively and efficiently.

If interested and qualified, please include Requisition # 2016-129 in the subject line when emailing resume to: careers@crisprtx.com.

For more information on CRISPR Therapeutics, please click here.