Press Release

CRISPR Therapeutics Announces the Presentation of Data on its Lead Program at the Upcoming 22nd European Hematology Association Annual Congress

BASEL, Switzerland and CAMBRIDGE, Mass., May 18, 2017 (GLOBE NEWSWIRE) -- CRISPR Therapeutics (NASDAQ:CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, today announced the selection of an abstract for presentation in the Presidential Symposium of the 22^ndCongress of the European Hematology Association (EHA) taking place in Madrid, Spain on June 22-25, 2017.

This abstract, selected by the Scientific Program Committee as one of the five best abstracts, will highlight recent work in re-creating the natural condition of hereditary persistence of fetal hemoglobin (HPFH) that is protective in sickle cell disease and beta thalassemia. The presentation will describe the ability to re-create specific HPFH gene variants in the intended target tissue, human primary CD34+ stem cells, the effect of these gene variants at re-creating the expression of protective fetal hemoglobin and progress in developing a product ready for clinical testing.

“We are pleased to have been selected as one of the five best abstracts at the leading global conference in the field of hematology. We remain on track to file a clinical trial application by the end of 2017 and the initiation of clinical trials in Europe in 2018,” said Dr. Rodger Novak, CEO of CRISPR Therapeutics AG.

Details of the presentation are as follows:

Title:	Re-Creating Hereditary Persistence of Fetal Hemoglobin (HPFH) with CRISPR/Cas9 To Treat Sickle Cell Disease (SCD) and Beta-Thalassemia (Beta-Thal)
Presenter:	Bill (Sven Ante) Lundberg, M.D., Chief Scientific Officer, CRISPR Therapeutics
Date / Time:	Friday, June 23, 4:00-4:15 PM (Central European time zone)
Session Title:	Presidential Symposium located in Hall A
Abstract:	S147

A copy of the EHA abstracts were made available May 18, 2016 through the EHA meeting website at www.ehaweb.org. Following the presentation, the data presented will be available under the “Investors & Media” section of the Company’s website at www.crisprtx.com and will also be webcast by the EHA.

About CRISPR Therapeutics

CRISPR Therapeutics is a leading gene-editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR / Cas9 gene-editing platform. CRISPR/Cas9 is a revolutionary technology that allows for precise, directed changes to genomic DNA. The company's multi-disciplinary team of world-class researchers and drug developers is working to translate this technology into breakthrough human therapeutics in a number of serious diseases. Additionally, CRISPR Therapeutics has established strategic collaborations with Bayer AG and Vertex Pharmaceuticals to develop CRISPR-based therapeutics in diseases with high unmet need. The foundational CRISPR / Cas9 patent estate for human therapeutic use was licensed from the company's scientific founder Emmanuelle Charpentier, Ph.D. CRISPR Therapeutics AG is headquartered in Basel, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, Massachusetts. For more information, please visit www.crisprtx.com.

Media Contacts:
Jennifer Paganelli
WCG on behalf of CRISPR
1-347-658-8290
jpaganelli@wcgworld.com

Investor Contact:
Chris BrinzeyWestwicke Partners for CRISPR
1-339-970-2843
chris.brinzey@westwicke.com

CRISPR Therapeutics AG